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Vanc App 'Vancomycin First-dose Trough Dose Adjustment Calculator for Young Infants' is a dose adjustment calculator for young infants receiving intermittent vancomycin. It recommends if a dose adjustment is required to achieve an AUC24-48 of 400-650 mg/L·h (24-48 hours after commencing vancomycin) based on an individual’s post-menstrual age, weight, serum creatinine level, dose, dosing interval and first-dose trough level (taken immediately prior to the time the second dose is due). If the steady state trough is < 5 mg/L or > 20 mg/L, dose interval will be adjusted. Vanc App calculators are intended for use in young infants aged 0 to 90 days with a post-menstrual age ≥ 25 weeks and weight ≥ 500 grams. They have not been validated in young infants with abnormal renal function, those receiving extracorporeal membrane oxygenation or renal replacement therapy. Vanc App should not be used for young infants with a known allergy to glycopeptide antibiotics. Vanc App calculators are based on a published population pharmacokinetic model (Gwee et al, JAMA Pediatrics 2019 173:8). Read the full Terms of Use.
Vancomycin First-dose Trough Dose Adjustment Calculator For Young Infants